The Pharmacologist (with apologies to Edgar Allan Poe)

 

Once upon a midnight dreary, while I pondered, weak and weary,

Over many a quaint and curious volume of receptor lore,
While I nodded, nearly napping, ev’ning study energy sapping,
Suddenly there came a tapping, gloomy thoughts rapping, rapping at memory’s door.
“So many drugs!” I cried, “sapping my memory store!”
“So many drugs! Can’t learn no more…

Back into the chamber turning, all my soul within me burning,
Soon again I heard a tapping, something louder than before,
“Surely,” said I, “surely, there’s a sensibleness to pharmacology.
Let me see, then, what thereat is, and this mystery explore.
If my heart be still, epinephrine will make it beat once more.
Or for anaphylaxis but nothing more.Nicotine is worth a poke, chewed, sniffed, or even smoked:
A full agonist, toked, will open sodium pores.
But before you ever start, know the drug will steal your heart,
And you may find yourself dart through craving’s door;
Try varenicline to keep from taking more.
Varenicline alone? Partial agonist and nothing more.Open here I flung the shutter, when, with many a flirt and flutter,
In there stepped a stately raven, of the saintly days of yore.
Suddenly my heart was racing; verapamil, thought I, would slow the pacing.
Or adenosine, intravenous, would sinus rhythm restore.
The raven gazed down at me, from just above my chamber door,
Perched, and gazed, and nothing more.Then this ebony bird beguiling my sad fancy into smiling,
By the grave and stern decorum of the countenance it wore,
“When motor control is a-failing, pramipexole is amazing,
And levodopa with carbidopa will movement restore,
Add bromocriptine or ropinirole, for this and more.”
Quoth the raven, “Evermore.”Deep into the darkness peering, long I lay, sleep not appearing;
Zolpidem prescription wishing I had filled before.
Diazepam gives sedation; oxazepam, buspirone ease trepidation.
Grave seizure? Lorazepam for cessation and control restore.
Valproate is broad-spectrum but watch liver function score;
Ethosuximide for absence, but only this and nothing more.

Ah, distinctly I remembered, rivastigmine was a member,
Memantine, too, spared dying embers of memory from Alzheimer’s door.
For loss of interest from depression, paroxetine effects prevention
Citalopram, too, restores attention, attention to life’s charms once more.
Hallucinations and delusion? Olanzepine will sanity restore;
Haloperidol, too, but extrapyramidal symptoms to watch out for.

To numb the tooth in dental pain, none’s as good as lidocaine;
Injected, causes ache to drain, by block of sodium pores.
Cocaine surely has a part, but locals can make arrhythmias start.
Ere surgery to heal the heart isoflurane closes the waking door;
Add nitrous oxide to lower the MAC score
Nitrous alone? Dental work, and nothing more.

To fathom Hell or soar angelic, just take a pinch of psychedelic
Hofmann’s potion LSD or Sasha Shulgin’s 2C-B give access to your core.
Psilocybin and mescaline, mushroom and cactus friends,
And dimethyltryptamine need serotonin receptors to open the door
To synesthesia, Day-Glo colors galore.
And for the Godhead, ayahuasca of shaman’s ancient lore.

But the raven still beguiling all my sad soul into smiling,
Straight I wheeled a cushioned seat in front of bird, and bust, and door;
A ‘statin’s good for lipid elevation, cholestipol, too, but get constipation;
For triglyceride exaggeration, fenofibrate will lower level restore.
Niacin will raise HDL too, if needing more.
Add ezetimibe to block the fat from McDonald’s store.

On my mantle raven jeering, midterm is now fast appearing,
Even now I hear Cozzi urge me on to more.
Morphine’s best for cancer pain, codeine for the cough again,
Naloxone for the overdose, to breathe again and consciousness restore.
Lithium to stop bipolar’s revolving door,
Add gabapentin or topiramate if needing more.

Presently my soul grew stronger; hesitating then no longer,
“Pharmacology” I cried, “is a subject I adore!”
Never nodding, no more napping, amphetamine keeps synapses snapping,
As my neurons begin mapping, mapping my memory stores.
“Acetylcholine,” I muttered, “mapping my memory stores.
Quoth the raven, “Evermore.”

©Nicholas V. Cozzi, Ph.D.

Professor of Pharmacology at the University of Wisconsin School of Medicine and Public Health

 

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